Chiral Precursors

Many biological substances have one chiral centre and therefore present two enantiomeric forms. Generally, only one of these forms has the desired biological activity. The inactive enantiomer dilutes the biological activity and acts as an impurity. Despite the advantages of enantiomerically pure drugs, most of synthetic chiral substances are commercial as racemic mixture because pure enantiomeriers are difficult and expensive to produce. Consequently, there is a growing need to develop reliable, efficient and scalable methods to produce pure enantiomers, particularly for the synthesis of biologically active natural products. Solchemar has developed new technologies to produce enantiomeric pure compounds, nomedamente, dicarboxylic acid monomethyl ester. This compound is an important chiral unit, since several functionalizations of the cyclohexane ring are possible, using the carboxylic group, the methoxycarbonyl group and the carbon-carbon double bond. This compound can be easily converted to biologically active compounds such as:

(-) Fortamine
Compactin
Mevinolin
Brefeldin A
Prostaglandins
Carbacyclin
Pentalenolactone
(+) Aucantene
Synton of HIV-protease inhibitor
Synton of vitamin D3
NMDA antagonist
Anticapsin
Papuamine